Prostate cancer (PC) is the second most common cancer in men worldwide. Due to the large-
scale sequencing efforts, there is currently a better understanding of the genomic landscape …

The protective ozone layer is continually depleting due to the release of deteriorating
environmental pollutants. The diminished ozone layer contributes to excessive exposure of …

In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO)
target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins …

Abstract Background Germ cell tumors (GCTs) are developmental cancers, tightly linked to
embryogenesis and germ cell development. The recent and expanding field of RNA …

The response to a DNA double-stranded break in mammalian cells is a process of sensing
and signalling the lesion. It results in halting the cell cycle and local transcription and in the …

Purpose The transcription factor NF-E2-related factor 2 (NRF2) is a master regulator widely
involved in essential cellular functions such as DNA repair. By clarifying the upstream and …

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence.
Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they …

Eukaryotic cells are constantly exposed to both endogenous and exogenous stressors that
promote the induction of DNA damage. Of this damage, double strand breaks (DSBs) are the …

Nuclear lamins are ancient type V intermediate filaments with diverse functions that include
maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin …

The integrity and regulation of the nuclear lamina is essential for nuclear organization and
chromatin stability, with its dysregulation being linked to laminopathy diseases and cancer …