Applications of morita-baylis-hillman reaction to the synthesis of natural products and drug molecules

S Bhowmik, S Batra - Current Organic Chemistry, 2014 - ingentaconnect.com
The synthesis of complex natural products from simple and common intermediates has been
one of the major goals in synthetic organic chemistry. Toward this objective, if such simple …

[HTML][HTML] The Chemistry and Pharmacology of Fungal Genus Periconia: A Review

A Azhari, U Supratman - Scientia Pharmaceutica, 2021 - mdpi.com
Periconia is filamentous fungi belonging to the Periconiaceae family, and over the last 50
years, the genus has shown interest in natural product exploration for pharmacological …

[HTML][HTML] Current synthetic approaches to the synthesis of carbasugars from non-carbohydrate sources

A Zorin, L Klenk, T Mack, HP Deigner… - Topics in Current …, 2022 - Springer
Carbasugars are a group of carbohydrate derivatives in which the ring oxygen is replaced
by a methylene group, producing a molecule with a nearly identical structure but highly …

Application of a tandem seleno-michael/aldol reaction in the total syntheses of (+)-Pericosine B,(+)-Pericosine C,(+)-COTC and 7-chloro-analogue of (+)-Gabosine C

N Biduś, P Banachowicz, S Buda - Tetrahedron, 2020 - Elsevier
Abstract Synthesis of (+)-Pericosine B,(+)-Pericosine C,(+)-COTC and a 7-chloro-analogue
of (+)-Gabosine C was achieved via tandem seleno-Michael/aldol reactions as key steps …

Total Syntheses of (+)-Gabosine P,(+)-Gabosine Q,(+)-Gabosine E,(−)-Gabosine G,(−)-Gabosine I,(−)-Gabosine K,(+)-Streptol, and (−)-Uvamalol A by a Diversity …

P Yuan, X Liu, X Yang, Y Zhang… - The Journal of Organic …, 2017 - ACS Publications
A new diversity-oriented approach to C7-cyclitols, which possess a broad spectrum of
biological activities, is developed. The key polyoxygenated intermediates with different O …

Synthesis of marine natural product (−)-pericosine E

K Mizuki, K Iwahashi, N Murata, M Ikeda, Y Nakai… - Organic …, 2014 - ACS Publications
The first synthesis of (−)-pericosine E (6), a metabolite of the Periconia byssoides OUPS-
N133 isolated originally from the sea hare Aplysia kurodai, has been achieved. Efficient and …

A divergent strategy to synthesize gabosines featuring a switchable two-way aldol cyclization

X Yang, P Yuan, F Shui, Y Zhou, X Chen - Organic & Biomolecular …, 2019 - pubs.rsc.org
Gabosines and their natural analogues, belonging to C7 carbasugars, have attracted great
attention in synthesis due to their rich structural variety and promising biological activities. A …

L-Rhamnulose-1-phosphate and L-fuculose-1-phosphate aldolase mediated multi-enzyme cascade systems for nitrocyclitol synthesis

FC Bres, C Guérard-Hélaine, V Hélaine… - Journal of Molecular …, 2015 - Elsevier
One-pot multistep stereoselective cascade reactions were implemented for the
straightforward synthesis of various nitrocyclitols. Two kinases, an aldolase and a …

Kinetic and mechanistic investigations of the Baylis–Hillman reaction in ionic liquids

A Singh, A Kumar - RSC Advances, 2015 - pubs.rsc.org
We report here a quantitative study of the kinetics and mechanism of the Baylis–Hillman
reaction in the presence of ionic liquids as solvent media. Apparently, a simple Baylis …

[HTML][HTML] Gram-scale carbasugar synthesis via intramolecular seleno-Michael/aldol reaction

P Banachowicz, S Buda - RSC advances, 2019 - pubs.rsc.org
Carbasugars represent an important category of natural products possessing a broad
spectrum of biological activities. Lots of effort has been done to develop gram scale …