[HTML][HTML] Saliva–a new opportunity for fluid biopsy

Z Huang, X Yang, Y Huang, Z Tang, Y Chen… - Clinical Chemistry and …, 2023 - degruyter.com
Saliva is a complex biological fluid with a variety of biomolecules, such as DNA, RNA,
proteins, metabolites and microbiota, which can be used for the screening and diagnosis of …

[HTML][HTML] Salivary biomarkers in oral squamous cell carcinoma: a proteomic overview

G Riccardi, MG Bellizzi, I Fatuzzo, F Zoccali… - Proteomes, 2022 - mdpi.com
Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent cancers
worldwide. Endoscopic methods may be useful in the evaluation of oral injuries even though …

[HTML][HTML] Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

R Arora, C Cao, M Kumar, S Sinha, A Chanda… - Nature …, 2023 - nature.com
The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix …

C Guo, X Qu, X Tang, Y Song, J Wang… - Clinical and …, 2023 - Wiley Online Library
Background The mechanism underlying cervical carcinogenesis that is mediated by
persistent human papillomavirus (HPV) infection remains elusive. Aims Here, for the first …

[HTML][HTML] The use of salivary levels of matrix metalloproteinases as an adjuvant method in the early diagnosis of oral squamous cell carcinoma: a narrative literature …

M Monea, AM Pop - Current Issues in Molecular Biology, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with increased
mortality, in which the early diagnosis is the most important step in increasing patients' …

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and …

S Chakraborty, K Ramasubbu… - Reviews in Medical …, 2023 - Wiley Online Library
Head and neck cancer, one of the most commonly prevalent malignancies globally is a
complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx …

Realizing the clinical utility of saliva for monitoring oral diseases

JL Ebersole, H Hasturk, M Huber… - Periodontology …, 2024 - Wiley Online Library
In the era of personalized/precision health care, additional effort is being expended to
understand the biology and molecular mechanisms of disease processes. How these …

[HTML][HTML] Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity

G Kalló, PM Bertalan, I Márton, C Kiss… - International Journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck
cancer. Despite the genetic and environmental risk factors, OSCC is also associated with …

[HTML][HTML] Knockdown of lncRNA DLEU1 inhibits the tumorigenesis of oral squamous cell carcinoma via regulation of miR‑149‑5p/CDK6 axis

T Lv, H Liu, Y Wu, W Huang - Molecular medicine …, 2021 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC) is a frequent malignant tumor worldwide. Long non‑
coding RNAs (lncRNAs) are known to play key roles in different types of cancer, including …

[HTML][HTML] Clinical validation of a saliva-based matrix metalloproteinase-1 rapid strip test for detection of oral cavity cancer

LJ Chu, YT Chang, CY Chien, HC Chung, SF Wu… - Biomedical Journal, 2024 - Elsevier
Background We previously identified matrix metalloproteinase-1 (MMP-1) as one of the most
promising salivary biomarkers for oral squamous cell carcinoma (OSCC) and developed a …