Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

African sleeping sickness is endemic in sub-Saharan Africa where the WHO estimates that
60 million people are at risk for the disease. Human African trypanosomiasis (HAT) is 100 …

A majority of cancers fail to respond to immunotherapy due to the immunosuppressive tumor
microenvironment (TME), and metabolic regulation of the TME has been a promising …

Metastable phenotypic state transitions in cancer cells can lead to the development of
transient adaptive resistance or tolerance to chemotherapy. Here, we report that the …

1.1. Kinetoplastid Parasites as Pathogenic Parasites: Overview, Life Cycle, Relevance of
Life Stages to Health Over the past decade, neglected tropical diseases (NTDs) have seen a …

Background The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for
ATP production during infection of the mammalian host. The first step in this metabolic …

Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including
the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei …

There is an urgent need to develop new treatments for Chagas' disease. To identify drug
targets, it is important to understand the basic biology of Trypanosoma cruzi, in particular …

Aldolase (ALD) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of
Trypanosoma brucei are considered to be promising targets for chemotherapeutic treatment …

Background Trypanosoma cruzi is the etiological agent of Chagas' disease, an endemic
infection that causes thousands of deaths every year in Latin America. Therapeutic options …