Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are
expressed by T cells and various other immune and non-immune cell types are central to T …

▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis
factor receptor/tumor necrosis factor superfamily and are expressed on activated CD4+ and …

Interactions between co-stimulatory ligands and their receptors are crucial for the activation
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now …

Regulatory T (T reg) cells are the major obstacle to cancer immunotherapy, and their
depletion promptly induces conversion of peripheral precursors into T reg cells. We show …

An emerging immunotherapeutic strategy for T-cell-mediated diseases is to directly target
antigen-specific T cells that are responsible for the clinical effects, without causing general …

Abstract OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is
transiently expressed on T cells after T-cell receptor (TCR) ligation. Both naive and activated …

The generation and maintenance of immune responses are controlled by both co-
stimulatory and co-inhibitory signalling through T cell co-receptors, many of which belong to …

A recent workshop on" Dendritic Cells: Biology and Therapeutic Applications," sponsored by
the Juan March Foundation, brought together basic and clinical research scientists to …

Abstract OX40 ligand (OX40L), the ligand for OX40 on activated CD4+ T cells, has adjuvant
properties for establishing effective T-cell immunity, a potent effector arm of the immune …