Antisense transcription, which was initially considered by many as transcriptional noise, is
increasingly being recognized as an important regulator of gene expression. It is …

Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …

Dynamic regulation is a promising strategy for fine-tuning metabolic fluxes in microbial cell
factories. However, few of these synthetic regulatory systems have been developed for …

Genes in prokaryotic genomes are often arranged into clusters and co-transcribed into
polycistronic RNAs. Isolated examples of polycistronic RNAs were also reported in some …

SUMMARY A substantial amount of antisense transcription is a hallmark of gene expression
in eukaryotes. However, antisense transcription was first demonstrated in bacteria almost 50 …

Phages express anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems that would
otherwise destroy their genomes. Most acr genes are located adjacent to anti-CRISPR …

How new functions arise de novo is a fundamental question in evolution. We studied de
novo evolution of promoters in Escherichia coli by replacing the lac promoter with various …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Genomic imprinting is an epigenetic process leading to parental-specific expression of one
to two percent of mammalian genes that offers one of the best model systems for a molecular …

Transcriptional interference is the in cis suppression of one transcriptional process by
another. Mathematical modeling shows that promoter occlusion by elongating RNA …