The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with
two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are …

Ceramides are important participants of signal transduction, regulating fundamental cellular
processes. Here we report the mechanism for activation of p53 tumor suppressor by C16 …

Although intracellular biomarkers can be imaged with fluorescent dye (s)-labeled antibodies,
the use of such probes for precise imaging of intracellular biomarkers in living cells remains …

Restoring p53 levels through disruption of p53–MDM2 interaction has been proved to be a
valuable approach in fighting cancer. We herein report the synthesis and evaluation of …

We report on the synthesis and biological evaluation of a library of twenty-three
spiropyrazoline oxindoles. The antiproliferative activity of the chemical library was evaluated …

The design and synthesis of a library of twenty-six spirotriazoline oxindoles and their in vitro
evaluation as potential anticancer agents is reported. The antiproliferative activity of the …

The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of
interactions with multiple partners and functions. Intrinsically disordered regions help to …

This paper reports the synthesis and biological evaluation of thirty one spirooxadiazoline
oxindoles as potential anticancer agents. Nine compounds showed an antiproliferative …

Based on structural optimization work, probes 9–11 with practical activity and selectivity in
tissue as well as living cell lines are well designed and synthesized. All the probes showed …

In this article, we describe a no‐wash small‐molecule fluorescent probe for detecting and
imaging p53–MDM 2 protein–protein interaction based on an environment‐sensitive …