This review discusses the need for tracheal replacement, distinct from resection with primary
anastomosis, the requirements for replacement, and the many efforts over the past century to …

Reconstruction of long-segment tracheal defects requires a vascularized allograft. We report
successful tracheal allotransplantation after indirect revascularization of the graft in a …

A recent revival of global interest for reconstruction of long-segment tracheal defects, which
represents one of the most interesting and complex problems in head and neck and thoracic …

The first vascularized tracheal allotransplantation was performed in 2008.
Immunosuppression was stopped after forearm implantation and grafting of the recipient …

Objective: To provide a state-of-the-art review discussing recent achievements in tissue
engineered tracheal reconstruction. Data Sources and Review Methods: A structured …

Tissue engineering is the interdisciplinary field of principles of engineering and life sciences.
Most of the financial support for this field originates in the private sector, creating a relative …

Current methods to replace damaged upper airway epithelium with exogenous cells are
limited. Existing strategies use grafts that lack mucociliary function, leading to infection and …

OBJECTIVES: The major problems in the development of tracheal prosthesis are
anastomotic dehiscence and stenosis, caused by poor epithelialization of the prosthetic …

Breathing, being predominantly an automatic action, is often taken for granted. However,
respiratory diseases affect millions of people globally, emerging as one of the major causes …

This will enable wider application of tracheal allotransplantation for patients in need of
complex reconstructive surgery for airway defects that are not amenable to standard …