Uptake transporters at the blood–brain barrier and their role in brain drug disposition
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …
[HTML][HTML] Unveiling the next generation of bisphenol analogs and their impact on human health using in vitro methods
Bisphenols are a group of organic compounds used frequently in industries to make plastics,
coatings, and resins. These compounds recently gained attention due to their potential …
coatings, and resins. These compounds recently gained attention due to their potential …
Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where …
G Vijaywargi, S Kollipara, T Ahmed… - … & Drug Disposition, 2023 - Wiley Online Library
The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK)
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …
Recent advancements on in vitro blood-brain barrier model: A reliable and efficient screening approach for preclinical and clinical investigation
Introduction The efficiency of brain therapeutics is greatly hindered by the blood-brain
barrier (BBB). BBB's protective function, selective permeability, and dynamic functionality …
barrier (BBB). BBB's protective function, selective permeability, and dynamic functionality …
Interspecies differences in mammalian susceptibility to legacy POPs and trace metals using skin fibroblast cells
Y Sun, Y Zeng, IR Rajput, E Sanganyado, R Zheng… - Environmental …, 2022 - Elsevier
The susceptibility to trace metals and legacy POPs is different between terrestrial and
marine mammals. In this study, we established the first cell line from Indo-Pacific finless …
marine mammals. In this study, we established the first cell line from Indo-Pacific finless …
Applicability of MDR1 Overexpressing Abcb1KO-MDCKII Cell Lines for Investigating In Vitro Species Differences and Brain Penetration Prediction
E Sóskuti, N Szilvásy, C Temesszentandrási-Ambrus… - Pharmaceutics, 2024 - mdpi.com
Implementing the 3R initiative to reduce animal experiments in brain penetration prediction
for CNS-targeting drugs requires more predictive in vitro and in silico models. However …
for CNS-targeting drugs requires more predictive in vitro and in silico models. However …
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug …
K Langthaler, CR Jones, L Saaby, C Bundgaard… - Fluids and Barriers of …, 2024 - Springer
Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS
drug discovery and development. While in vivo Kp, uu, brain estimates are the gold standard …
drug discovery and development. While in vivo Kp, uu, brain estimates are the gold standard …
FDA 现代化法案2.0 给疾病动物模型发展带来的启示和思考
万颖寒， 顾也欣， 袁雨浓， 汤忞， 鲁立 - 实验动物与比较医学, 2023 - slarc.org.cn
实验动物是生命科学研究和生物医药产业发展的基础条件, 是科学探索和医疗健康事业中不可或
缺的技术支撑. 科学地开发疾病动物模型对生物医药科研和产业发展意义重大 …
缺的技术支撑. 科学地开发疾病动物模型对生物医药科研和产业发展意义重大 …
EFSA Pilot Project on New Approach Methodologies (NAMs) for Tebufenpyrad Risk Assessment. Part 1. Development of Physiologically‐Based Kinetic (PBK) Model …
J Henri, L Lehegarat, A Cavelier… - EFSA Supporting …, 2023 - Wiley Online Library
Tebufenpyrad is a pesticide active substance used as insecticide, for which the mechanism
of action is an inhibition Complex I of the Mitochondrial Electron Transport Chain (ETC). In …
of action is an inhibition Complex I of the Mitochondrial Electron Transport Chain (ETC). In …
Special issue on applications of in vitro, in vivo, and modeling and simulation tools for central nervous system drug disposition.
L Di - Biopharmaceutics & Drug Disposition, 2023 - search.ebscohost.com
Blood-brain barrier in drug discovery: Optimizing brain exposure of CNS drugs and
minimizing brain side effects for peripheral drugs. Cerebrospinal fluid (CSF) drug …
minimizing brain side effects for peripheral drugs. Cerebrospinal fluid (CSF) drug …