Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world
with an incidence of 4.2/100 000/year. The incidence increases to more than 30/100 …

Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

The ribosome is an RNA-protein complex that is essential for translation in all domains of
life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA). While …

Better understanding on interactions between SARS‐CoV‐2 and host cells should help to
identify host factors that may be targetable to combat infection and COVID‐19 pathology. To …

Circular RNAs (circRNAs) represent a large group of non-coding RNAs that are widely
detected in mammalian cells. Although most circRNAs are generated in a sense orientation …

Increased rates of ribosome biogenesis have been recognized as hallmarks of many
cancers and are associated with poor prognosis. Using a CRISPR synergistic activation …