Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Preclinical models (typically the ovariectomized rat and genetically altered mice) have
underpinned much of what we know about skeletal biology. They have been pivotal for …

Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular
mechanisms that establish and maintain bone quality, independent of bone mass, are …

Abstract Intracellular phosphoinositide 3-kinase (PI3K) signaling is activated by multiple
bone-active receptors. Genetic mutations activating PI3K signaling are associated with …

Bone morphogenetic proteins (BMPs) are potent osteoinductive agents for bone tissue
engineering. In order to define optimal properties of a novel autologous bone graft substitute …

Bone strength is controlled by both bone mass, and the organization and quality of the bone
material. The current standard method for measuring bone mass in mouse and rat studies is …

Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia characterized by high
fracture rates and broad variations in clinical manifestations ranging from mild to …

Bone strength is partially determined during cortical bone consolidation, a process
comprising coalescence of peripheral trabecular bone and its progressive mineralisation …

Suppressor of cytokine signaling (SOCS) proteins are significant regulators of cellular
immune responses. Therefore, the role of SOCS in bone-inflammatory disorders, including …

Abstract Individuals with Type-2 Diabetes (T2D) have an increased risk of bone fracture,
without a reduction in bone mineral density. It is hypothesised that the hyperglycaemic state …