Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has
attracted an exponentially growing interest. A key driver for this trend was the ability to image …

Background Plasma assays for the detection of Alzheimer's disease neuropathological
changes are receiving ever increasing interest. The concentration of plasma glial fibrillary …

Reactive astrocytes play an important role in the development of Alzheimer's disease (AD).
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …

Drug resistance in cancer is determined by genetic mutations and adaptations of tumor cells
to drug treatments, raising a challenge in the treatment of cancer. Factors such as prolonged …

Reactive astrogliosis accompanies the two neuropathological hallmarks of Alzheimer's
disease (AD)—Aβ plaques and neurofibrillary tangles—and parallels neurodegeneration in …

Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-
tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau …

Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly
driven by mutations in the NPC1 gene, causing lipid accumulation within late endosomes …

This paper provides an overview of the role of neuroinflammation in Alzheimer's disease
and other neurodegenerative diseases, highlighting the potential of anti-inflammatory …

Neuroinflammation is associated with the pathophysiologies of neurodegenerative and
psychiatric disorders. Evaluating neuroinflammation using positron emission tomography …

Background Progressive supranuclear palsy (PSP) is a primary 4-repeat tauopathy with
diverse clinical phenotypes. Previous post-mortem studies examined tau deposition …