The oral microbiota: dynamic communities and host interactions

RJ Lamont, H Koo, G Hajishengallis - Nature reviews microbiology, 2018 - nature.com
The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as
dental caries and periodontitis, two of the most prevalent microbially induced disorders …

Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments

WH Bowen, RA Burne, H Wu, H Koo - Trends in microbiology, 2018 - cell.com
Biofilms are microbial communities embedded within an extracellular matrix, forming a
highly organized structure that causes many human infections. Dental caries (tooth decay) is …

The structure of dental plaque microbial communities in the transition from health to dental caries and periodontal disease

AM Valm - Journal of molecular biology, 2019 - Elsevier
The human oral cavity harbors diverse communities of microbes that live as biofilms: highly
ordered, surface-associated assemblages of microbes embedded in an extracellular matrix …

Early childhood caries: epidemiology, aetiology, and prevention

F Meyer, J Enax - International journal of dentistry, 2018 - Wiley Online Library
Early childhood caries (ECC) is one of the most prevalent diseases in children worldwide.
ECC is driven by a dysbiotic state of oral microorganisms mainly caused by a sugar‐rich …

Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries

D Kim, JP Barraza, RA Arthur, A Hara… - Proceedings of the …, 2020 - National Acad Sciences
Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms.
Streptococcus mutans, a biofilm-former, has been consistently associated with severe …

Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis

J Xiao, X Huang, N Alkhers, H Alzamil, S Alzoubi… - Caries …, 2018 - karger.com
Oral Candida albicans has been detected in children with early childhood caries (ECC) and
has demonstrated cariogenic traits in animal models of the disease. Conversely, other …

Ferumoxytol nanoparticles target biofilms causing tooth decay in the human mouth

Y Liu, Y Huang, D Kim, Z Ren, MJ Oh, DP Cormode… - Nano …, 2021 - ACS Publications
Severe tooth decay has been associated with iron deficiency anemia that disproportionally
burdens susceptible populations. Current modalities are insufficient in severe cases where …

Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites

D Kim, A Sengupta, THR Niepa, BH Lee, A Weljie… - Scientific Reports, 2017 - nature.com
Candida albicans is frequently detected with heavy infection of Streptococcus mutans in
plaque-biofilms from children affected with early-childhood caries, a prevalent and costly …

Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions

Z Ren, H Jeckel, A Simon-Soro… - Proceedings of the …, 2022 - National Acad Sciences
Fungi and bacteria often engage in complex interactions, such as the formation of
multicellular biofilms within the human body. Knowledge about how interkingdom biofilms …

Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

Y Liu, PC Naha, G Hwang, D Kim, Y Huang… - Nature …, 2018 - nature.com
Ferumoxytol is a nanoparticle formulation approved by the US Food and Drug
Administration for systemic use to treat iron deficiency. Here, we show that, in addition …