Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
[HTML][HTML] Recent advances in high-throughput biofluid metabotyping by direct infusion and ambient ionization mass spectrometry
V Plekhova, K De Windt, M De Spiegeleer… - TrAC Trends in …, 2023 - Elsevier
Biofluid metabolomics is a popular tool for biomarker discovery to decipher disease-,
genetics-, and exposure-related metabolic alterations and is an essential component for …
genetics-, and exposure-related metabolic alterations and is an essential component for …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
Abstract Individuals with South Asian ancestry have a higher risk of heart disease than other
groups but have been largely excluded from genetic research. Using data from 22,000 …
groups but have been largely excluded from genetic research. Using data from 22,000 …
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023 - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …
lipid-associated variants and understand the link between lipid species and cardiometabolic …
Association of physical activity with bioactive lipids and cardiovascular events
Background: To clarify the mechanisms underlying physical activity (PA)-related
cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and …
cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and …
Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction
associated with several diseases. Previous genome-wide association studies (GWAS) have …
associated with several diseases. Previous genome-wide association studies (GWAS) have …
Integrating common risk factors with polygenic scores improves the prediction of type 2 diabetes
Y Timasheva, Z Balkhiyarova, D Avzaletdinova… - International journal of …, 2023 - mdpi.com
We tested associations between 13 established genetic variants and type 2 diabetes (T2D)
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
in 1371 study participants from the Volga-Ural region of the Eurasian continent, and …
Universal genome-wide association studies: Powerful joint ancestry and association testing
D Shriner, AR Bentley, MH Gouveia, EF Heuston… - Human Genetics and …, 2023 - cell.com
The vast majority of human populations and individuals have mixed ancestry. Consequently,
adjustment for locus-specific ancestry is essential for genetic association studies. To …
adjustment for locus-specific ancestry is essential for genetic association studies. To …
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistanis and Bangladeshis
Abstract Background Individuals with South Asian ancestry have higher risk of heart disease
than other groups in Western countries; however, most genetic research has focused on …
than other groups in Western countries; however, most genetic research has focused on …