Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

We describe a new implementation for the reconstruction of helical assemblies in the
empirical Bayesian framework of RELION. Our approach calculates optimal linear filters for …

Cryo-EM has revealed the structures of many challenging yet exciting macromolecular
assemblies at near-atomic resolution (3–4.5 Å), providing biological phenomena with …

Bacteria utilise specialised protein secretion systems to interact with host organisms,
competitor bacteria, and the environment. The Type VI secretion system (T6SS) is a versatile …

The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …

Many bacteria have evolved specialized nanomachines with the remarkable ability to inject
multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as …

Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver
toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial …

Several systems, including contractile tail bacteriophages, the type VI secretion system and
R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell …

The type VI secretion system (T6SS) is a bacterial nanomachine used to inject effectors into
prokaryotic or eukaryotic cells and is thus involved in both host manipulation and …