Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Exosomes derived from mesenchymal stem cells (MSCs) are known to participate in
myocardial repair after myocardial infarction (MI), but the mechanism remains unclear. Here …

Background & Aims Etrasimod (APD334) is an oral, selective sphingosine 1-phosphate
receptor modulator in development for immune-mediated inflammatory disorders. We …

Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …

Background: Sphingolipids have recently emerged as a biomarker of recurrence and
mortality after myocardial infarction (MI). The increased ceramide levels in mammalian heart …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

Psoriasis is a chronic inflammatory condition affecting approximately 2% to 3% of the global
population. The pathogenesis of psoriasis is complex, involving immune dysregulation …

Background Rheumatoid arthritis (RA) is an angiogenesis-dependent disease caused by
the imbalance of pro-and anti-angiogenic factors. More effective strategies to block synovial …

Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …