Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors
Alzheimer's disease (AD) is characterized by an imbalance between production and
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …
[HTML][HTML] Visualizing and trapping transient oligomers in amyloid assembly pathways
Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …
towards amyloid disease. However, understanding how such intermediates form, their …
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
Regulation of copper and iron homeostasis by metal chelators: A possible chemotherapy for Alzheimer's disease
A Robert, Y Liu, M Nguyen… - Accounts of chemical …, 2015 - ACS Publications
Conspectus With the increase of life expectancy of humans in more than two-thirds of the
countries in the World, aging diseases are becoming the frontline health problems …
countries in the World, aging diseases are becoming the frontline health problems …
Mechanistic insight into the design of chemical tools to control multiple pathogenic features in Alzheimer's disease
Conspectus Alzheimer's disease (AD) is the most common form of dementia and is
characterized by memory loss and cognitive decline. Approximately 50 million people …
characterized by memory loss and cognitive decline. Approximately 50 million people …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
Copper-targeting approaches in Alzheimer's disease: how to improve the fallouts obtained from in vitro studies
C Esmieu, D Guettas, A Conte-Daban… - Inorganic …, 2019 - ACS Publications
According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn ions, bound to
the amyloid-β (Aβ) peptides are implicated in Alzheimer's disease (AD), a widespread …
the amyloid-β (Aβ) peptides are implicated in Alzheimer's disease (AD), a widespread …