Advances in screening hyperthermic nanomedicines in 3D tumor models
Hyperthermic nanomedicines are particularly relevant for tackling human cancer, providing
a valuable alternative to conventional therapeutics. The early-stage preclinical performance …
a valuable alternative to conventional therapeutics. The early-stage preclinical performance …
Can immunotherapy reinforce chemotherapy efficacy? a new perspective on colorectal cancer treatment
X He, H Lan, K Jin, F Liu - Frontiers in Immunology, 2023 - frontiersin.org
As one of the main threats to human life (the fourth most dangerous and prevalent cancer),
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …
[HTML][HTML] Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer …
X Lu, J Jin, Y Wu, J Lin, X Zhang, S Lu, J Zhang… - Bioactive Materials, 2025 - Elsevier
Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune
evasion, and their co-overexpression is strongly associated with a poor prognosis. However …
evasion, and their co-overexpression is strongly associated with a poor prognosis. However …
Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling
NA Leonard, SM Corry, E Reidy, H Egan, G O'Malley… - Iscience, 2024 - cell.com
Summary CMS4 colorectal cancer (CRC), based on the consensus molecular subtype
(CMS), stratifies patients with the poorest disease-free survival rates. It is characterized by a …
(CMS), stratifies patients with the poorest disease-free survival rates. It is characterized by a …
Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance
L Dadgar-Zankbar, Z Elahi, A Shariati… - Cell Communication and …, 2024 - Springer
Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal
cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is …
cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is …
Clinical challenges of consensus molecular subtype CMS4 colon cancer in the era of precision medicine
S Mouillet-Richard, A Cazelles, M Sroussi… - Clinical Cancer …, 2024 - AACR
Over the past decade, our understanding of the diversity of colorectal cancer has expanded
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …
[HTML][HTML] Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
Colorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes.
Despite considerable progress in development of CRC therapeutics, challenges remain …
Despite considerable progress in development of CRC therapeutics, challenges remain …
The clinical relevance of adjuvant chemotherapy in locally advanced rectal cancer patients achieving near pathological complete response following neoadjuvant …
Y Cai, M Chen, F Ye, Z Liu, S Luo, L Huang… - European Journal of …, 2024 - Elsevier
Background Near-pathological complete response (Near-pCR) patients constitute a distinct
subgroup with limited research attention. The clinical relevance of adjuvant chemotherapy …
subgroup with limited research attention. The clinical relevance of adjuvant chemotherapy …
Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer
DY Moss, C Brown, A Shaw, C McCann, N Lewis… - bioRxiv, 2024 - biorxiv.org
Therapy resistance is attributed to over 80% of cancer deaths per year emphasizing the
urgent need to overcome this challenge for improved patient outcomes. Despite its …
urgent need to overcome this challenge for improved patient outcomes. Despite its …