The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …

Predictive models are essential for advancing knowledge of brain disorders. High variation
in study outcomes hampers progress. To address the validity of predictive models, we …

Abnormal tactile response is an integral feature of Autism Spectrum Disorders (ASDs), and
hypo-responsiveness to tactile stimuli is often associated with the severity of ASDs core …

Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with
autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be …

Alterations in the balance between excitation and inhibition, especially in the brain's critical
developmental periods, are considered an integral part of the pathophysiology of autism …

Age-related macular degeneration (AMD) is the most common cause of untreatable
blindness in the developed world. Recently, CDHR1 has been identified as the cause of a …

Obesity is a pediatric epidemic that is more prevalent in children with developmental
disabilities. We hypothesize that soy protein-based diets increase weight gain and alter …

Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants
(CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of …

Background CREB-dependent transcription necessary for long-term memory is driven by
interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous …