In the pharmaceutical industry, the unexpected appearance of crystalline forms could impact
the therapeutic efficacy of an Active Pharmaceutical Ingredient (API). For quality control, a …

Mebendazole (MBZ) is a broad-spectrum active pharmaceutical ingredient (API) indicated
for treating parasitosis, and it has three solid-state forms, A, B, and C. These solid forms …

This work presents an evaluation of the analytical performance of three different portable
near-infrared (NIR) instruments (denominated Port. 1, Port. 2 and Port. 3) for quantifying …

Hydrates are common in pharmaceutical development, and the formation of hydrates affects
the performance of the final product. However, the role that water plays in crystal packing …

Structural polymorphism of active pharmaceutical ingredients (API) is a relevant concern for
the modern pharmaceutical industry, since different polymorphic forms may display …

This study investigated the influence of moisture and heat on the stability of mebendazole
polymorph C in tablets. The polymorphic forms of mebendazole display significant …

This work presents an analytical method based on terahertz-time domain spectroscopy (THz-
TDS) and partial least squares (PLS) regression models to quantify mebendazole (MBZ) …

In the present study, a simple method, based on diffuse reflectance FTIR spectroscopy
(DRIFTS) and artificial neural network (ANN) modeling is developed for the simultaneous …

Near-Infrared hyperspectral imaging (HSI-NIR) is a useful technique for pharmaceutical
research and industry alike. It can provide important surface information such as the …

This work evaluates the feasibility of using NIR spectroscopy for quantification of three
polymorphs of mebendazole (MBZ) in pharmaceutical raw materials. Thirty ternary mixtures …