Stem cell based therapies for age-related macular degeneration: the promises and the challenges
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
Transplantation of the RPE in AMD
S Binder, BV Stanzel, I Krebs, C Glittenberg - Progress in retinal and eye …, 2007 - Elsevier
The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper
between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane …
between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane …
[HTML][HTML] Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration
A Bi, J Cui, YP Ma, E Olshevskaya, M Pu, AM Dizhoor… - Neuron, 2006 - cell.com
The death of photoreceptor cells caused by retinal degenerative diseases often results in a
complete loss of retinal responses to light. We explore the feasibility of converting inner …
complete loss of retinal responses to light. We explore the feasibility of converting inner …
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
S Ooto, T Akagi, R Kageyama, J Akita… - Proceedings of the …, 2004 - National Acad Sciences
It has long been believed that the retina of mature mammals is incapable of regeneration. In
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …
Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease
RD Lund, S Wang, B Lu, S Girman, T Holmes… - Stem …, 2007 - academic.oup.com
Progressive photoreceptor degeneration resulting from genetic and other factors is a leading
and largely untreatable cause of blindness worldwide. The object of this study was to find a …
and largely untreatable cause of blindness worldwide. The object of this study was to find a …
[HTML][HTML] Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration
Purpose Our objective was to comprehensively assess the nature and chronology of neural
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …
[HTML][HTML] In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells
M Haruta, Y Sasai, H Kawasaki… - … & visual science, 2004 - jov.arvojournals.org
purpose. To determine whether primate embryonic stem (ES) cell-derived pigment epithelial
cells (ESPEs) have the properties and functions of retinal pigment epithelial (RPE) cells in …
cells (ESPEs) have the properties and functions of retinal pigment epithelial (RPE) cells in …
RPE transplantation and its role in retinal disease
Retinal pigment epithelial (RPE) transplantation aims to restore the subretinal anatomy and
re-establish the critical interaction between the RPE and the photoreceptor, which is …
re-establish the critical interaction between the RPE and the photoreceptor, which is …
Treatment of retinitis pigmentosa with human umbilical cord cells
S Mistry, DJ Messina, IR Harris, AM Harmon… - US Patent …, 2008 - Google Patents
US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells - Google
Patents US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells …
Patents US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells …
[HTML][HTML] Remodeling of second-order neurons in the retina of rd/rd mutant mice
This is a brief review of data obtained by analyzing the morphology and the physiology of
the retinas in rd/rd and normal, wt mice, aged 10–90 days. Second-order neurons of the …
the retinas in rd/rd and normal, wt mice, aged 10–90 days. Second-order neurons of the …