Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Transplantation of the RPE in AMD

S Binder, BV Stanzel, I Krebs, C Glittenberg - Progress in retinal and eye …, 2007 - Elsevier
The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper
between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane …

[HTML][HTML] Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration

A Bi, J Cui, YP Ma, E Olshevskaya, M Pu, AM Dizhoor… - Neuron, 2006 - cell.com
The death of photoreceptor cells caused by retinal degenerative diseases often results in a
complete loss of retinal responses to light. We explore the feasibility of converting inner …

Potential for neural regeneration after neurotoxic injury in the adult mammalian retina

S Ooto, T Akagi, R Kageyama, J Akita… - Proceedings of the …, 2004 - National Acad Sciences
It has long been believed that the retina of mature mammals is incapable of regeneration. In
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …

Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease

RD Lund, S Wang, B Lu, S Girman, T Holmes… - Stem …, 2007 - academic.oup.com
Progressive photoreceptor degeneration resulting from genetic and other factors is a leading
and largely untreatable cause of blindness worldwide. The object of this study was to find a …

[HTML][HTML] Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration

RE Marc, BW Jones, CB Watt, F Vazquez-Chona… - Molecular …, 2008 - ncbi.nlm.nih.gov
Purpose Our objective was to comprehensively assess the nature and chronology of neural
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …

[HTML][HTML] In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells

M Haruta, Y Sasai, H Kawasaki… - … & visual science, 2004 - jov.arvojournals.org
purpose. To determine whether primate embryonic stem (ES) cell-derived pigment epithelial
cells (ESPEs) have the properties and functions of retinal pigment epithelial (RPE) cells in …

RPE transplantation and its role in retinal disease

L da Cruz, FK Chen, A Ahmado, J Greenwood… - Progress in retinal and …, 2007 - Elsevier
Retinal pigment epithelial (RPE) transplantation aims to restore the subretinal anatomy and
re-establish the critical interaction between the RPE and the photoreceptor, which is …

Treatment of retinitis pigmentosa with human umbilical cord cells

S Mistry, DJ Messina, IR Harris, AM Harmon… - US Patent …, 2008 - Google Patents
US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells - Google
Patents US7413734B2 - Treatment of retinitis pigmentosa with human umbilical cord cells …

[HTML][HTML] Remodeling of second-order neurons in the retina of rd/rd mutant mice

E Strettoi, V Pignatelli, C Rossi, V Porciatti, B Falsini - Vision research, 2003 - Elsevier
This is a brief review of data obtained by analyzing the morphology and the physiology of
the retinas in rd/rd and normal, wt mice, aged 10–90 days. Second-order neurons of the …