The circulating transcriptome as a source of cancer liquid biopsy biomarkers

C Sole, E Arnaiz, L Manterola, D Otaegui… - Seminars in cancer …, 2019 - Elsevier
Non-invasive biomarkers or liquid biopsies have the potential to revolutionise cancer patient
management as repeated sampling allows real-time monitoring of disease progression and …

[HTML][HTML] Circulating RNAs as new biomarkers for detecting pancreatic cancer

T Kishikawa, M Otsuka, M Ohno… - World journal of …, 2015 - ncbi.nlm.nih.gov
Pancreatic cancer remains difficult to treat and has a high mortality rate. It is difficult to
diagnose early, mainly due to the lack of screening imaging modalities and specific …

A molecular multi-gene classifier for disease diagnostics

R Lopez, R Wang, G Seelig - Nature chemistry, 2018 - nature.com
Despite its early promise as a diagnostic and prognostic tool, gene expression profiling
remains cost-prohibitive and challenging to implement in a clinical setting. Here, we …

A novel folic acid receptor-targeted drug delivery system based on curcumin-loaded β-cyclodextrin nanoparticles for cancer treatment

W Hong, F Guo, N Yu, S Ying, B Lou, J Wu… - Drug design …, 2021 - Taylor & Francis
Purpose A novel folate receptor-targeted β-cyclodextrin (β-CD) drug delivery vehicle was
constructed to improve the bioavailability, biosafety, and drug loading capacity of curcumin …

[HTML][HTML] Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

W Okajima, S Komatsu, D Ichikawa… - World Journal of …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), with its high incidence and mortality rate, is one of the
most common malignant tumors. Despite recent development of a diagnostic and treatment …

Circulating nucleic acids in plasma and serum (CNAPS): applications in oncology

JA González-Masiá, D García-Olmo… - OncoTargets and …, 2013 - Taylor & Francis
The presence of small amounts of circulating nucleic acids in plasma and serum (CNAPS) is
not a new finding. The verification that such amounts are significantly increased in cancer …

[HTML][HTML] Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids

T Imamura, S Komatsu, D Ichikawa… - World journal of …, 2016 - ncbi.nlm.nih.gov
Despite recent advances in surgical techniques and perioperative management, the
prognosis of pancreatic cancer (PCa) remains extremely poor. To provide optimal treatment …

Cell-free circulating plasma hTERT mRNA is a useful marker for prostate cancer diagnosis and is associated with poor prognosis tumor characteristics

JA March-Villalba, JM Martínez-Jabaloyas, MJ Herrero… - 2012 - journals.plos.org
Background Serum prostate-specific antigen (PSA) is the most widely used marker for
diagnosing prostate cancer (PCa). It lacks specificity and predictive value, resulting in …

Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease

L Terrin, E Rampazzo, S Pucciarelli, M Agostini… - Clinical Cancer …, 2008 - AACR
Purpose: Colorectal cancer (CRC) is one of the most common cancers in western countries.
Identification of circulating markers for CRC would optimize early stage diagnosis and the …

[HTML][HTML] Liquid biopsy of gastric cancer patients: circulating tumor cells and cell-free nucleic acids

M Tsujiura, D Ichikawa, H Konishi… - World journal of …, 2014 - ncbi.nlm.nih.gov
To improve the clinical outcomes of cancer patients, early detection and accurate monitoring
of diseases are necessary. Numerous genetic and epigenetic alterations contribute to …