ClC-6 is a late endosomal voltage-gated chloride-proton exchanger that is predominantly
expressed in the nervous system. Mutated forms of ClC-6 are associated with severe …

Endosomes and lysosomes are intracellular vesicular organelles with important roles in cell
functions such as protein homeostasis, clearance of extracellular material, and autophagy …

The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it
is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to …

Chloride is one of the most abundant anions in the human body; it is implicated in several
physiological processes such as the transmission of action potentials, transepithelial salt …

Melatonin is a pleiotropic biofactor and an effective antioxidant and free radical scavenger
and, as such, can be protective in oxidative stress‐related brain conditions including …

Objective The dysfunction of the CLCN4 gene can lead to X-linked intellectual disability and
Raynaud–Claes syndrome (MRXSRC), characterized by severe cognitive impairment and …

Objective The aim of this study was to explore the pathogenesis of CLCN6‐related disease
and to assess whether its Cl−/H+‐exchange activity is crucial for the biological role of ClC‐6 …

CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion
homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 …

We report two male fetuses born to a healthy unrelated couple, with agenesis of the corpus
callosum identified on detailed 20‐week ultrasound scans and confirmed by in‐utero MRI …

CLCs are dimeric membrane chloride channels and anion/proton exchangers regulating
processes such as muscle contraction and endo-lysosome acidification. Their activity is …