Small cell lung cancer: where do we go from here?
Small cell lung cancer (SCLC) is an aggressive disease that accounts for approximately
14% of all lung cancers. In the United States, approximately 31,000 patients are diagnosed …
14% of all lung cancers. In the United States, approximately 31,000 patients are diagnosed …
[HTML][HTML] Pathology and classification of SCLC
MG Raso, N Bota-Rabassedas, II Wistuba - Cancers, 2021 - mdpi.com
Simple Summary Small cell lung carcinoma (SCLC), is a high-grade neuroendocrine
carcinoma defined by its aggressiveness, poor differentiation, and somber prognosis. This …
carcinoma defined by its aggressiveness, poor differentiation, and somber prognosis. This …
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
Small cell lung cancer (SCLC) is an aggressive malignancy distinct from non–small cell lung
cancer (NSCLC) in its metastatic potential and treatment response. Using an integrative …
cancer (NSCLC) in its metastatic potential and treatment response. Using an integrative …
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
D Frescas, M Pagano - Nature Reviews Cancer, 2008 - nature.com
The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …
complex and coordinated process. It is regulated by phosphorylation—through the activity of …
The Rb/E2F pathway and cancer
JR Nevins - Human molecular genetics, 2001 - academic.oup.com
Over the past decade, studies focusing on the mechanisms controlling cellular proliferation
have converged with equally intensive efforts directed at the analysis of oncogenic pathways …
have converged with equally intensive efforts directed at the analysis of oncogenic pathways …
[HTML][HTML] Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
Y Lu, JM Thomson, HYF Wong, SM Hammond… - Developmental …, 2007 - Elsevier
The miR-17-92 locus encodes a cluster of 7 microRNAs transcribed as a single primary
transcript. It can accelerate c-Myc induced B cell lymphoma development and is highly …
transcript. It can accelerate c-Myc induced B cell lymphoma development and is highly …
Histone deacetylases, transcriptional control, and cancer
A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …
modification of nucleosomal histones, which converts regions of chromosomes into …
Notch signaling induces cell cycle arrest in small cell lung cancer cells
V Sriuranpong, MW Borges, RK Ravi, DR Arnold… - Cancer research, 2001 - AACR
Among the various forms of human lung cancer, small cell lung cancer (SCLC) exhibits a
characteristic neuroendocrine (NE) phenotype. Neural and NE differentiation in SCLC …
characteristic neuroendocrine (NE) phenotype. Neural and NE differentiation in SCLC …
Molecular genetics of small cell lung carcinoma
The etiology of small cell lung cancer (SCLC) is strongly tied to cigarette smoking, and now
there is considerable information concerning molecular abnormalities involved in the …
there is considerable information concerning molecular abnormalities involved in the …
Molecular histology of lung cancer: from targets to treatments
SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2015 - Elsevier
Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …