Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles
(< 200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug …

Lysosomal dysfunction has been increasingly linked to disease and normal ageing,.
Lysosomal membrane permeabilization (LMP), a hallmark of lysosome-related diseases …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a
fundamental process underlying hypercholesterolemia, a high blood cholesterol …