Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …

Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and
cellular decision-making during development. Wherein the epigenetic code maintains …

Transcription factor (TF) binding to DNA is crucial for transcriptional regulation. There are
multiple methods for mapping such binding. These methods balance between input …

In the earliest step of spliceosome assembly, the two splice sites flanking an intron are
brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism …

Exploring spatial organization and relationship of diverse biomolecules within cellular
nanoenvironments is important to elucidate the fundamental processes of life. However, it …

Multiple mechanisms of epigenetic control that include DNA methylation, histone
modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent …

The organisation of chromatin is first discussed to conclude that nucleosomes play both
structural and transcription-regulatory roles. The presence of nucleosomes makes difficult …

Abstract DOT 1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged
leukemia. Inhibitors have been developed to target DOT 1L activity in leukemia, but cellular …

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine
79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects …

Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently,
the transcription of long noncoding RNAs often overlaps with coding gene promoters …