Biological embedding of experience: a primer on epigenetics
MJ Aristizabal, I Anreiter… - Proceedings of the …, 2020 - National Acad Sciences
Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …
life health and well-being. Although extensive correlative data exist supporting the notion …
Epigenetic reprogramming during prostate cancer progression: a perspective from development
Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and
cellular decision-making during development. Wherein the epigenetic code maintains …
cellular decision-making during development. Wherein the epigenetic code maintains …
Fine-resolution mapping of TF binding and chromatin interactions
J Gutin, R Sadeh, N Bodenheimer, D Joseph-Strauss… - Cell reports, 2018 - cell.com
Transcription factor (TF) binding to DNA is crucial for transcriptional regulation. There are
multiple methods for mapping such binding. These methods balance between input …
multiple methods for mapping such binding. These methods balance between input …
The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
Y Leader, G Lev Maor, M Sorek, R Shayevitch… - Nature …, 2021 - nature.com
In the earliest step of spliceosome assembly, the two splice sites flanking an intron are
brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism …
brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism …
Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications
F Chen, M Bai, X Cao, J Xue, Y Zhao, N Wu… - Nature …, 2021 - nature.com
Exploring spatial organization and relationship of diverse biomolecules within cellular
nanoenvironments is important to elucidate the fundamental processes of life. However, it …
nanoenvironments is important to elucidate the fundamental processes of life. However, it …
Bivalent epigenetic control of oncofetal gene expression in cancer
Multiple mechanisms of epigenetic control that include DNA methylation, histone
modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent …
modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent …
Histone post-translational modifications and nucleosome organisation in transcriptional regulation: some open questions
J Castillo, G López-Rodas, L Franco - Protein Reviews: Volume 18, 2017 - Springer
The organisation of chromatin is first discussed to conclude that nucleosomes play both
structural and transcription-regulatory roles. The presence of nucleosomes makes difficult …
structural and transcription-regulatory roles. The presence of nucleosomes makes difficult …
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma
Abstract DOT 1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged
leukemia. Inhibitors have been developed to target DOT 1L activity in leukemia, but cellular …
leukemia. Inhibitors have been developed to target DOT 1L activity in leukemia, but cellular …
Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism
T van Welsem, T Korthout, R Ekkebus… - Nucleic acids …, 2018 - academic.oup.com
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine
79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects …
79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects …
Fine chromatin-driven mechanism of transcription interference by antisense noncoding transcription
JK Gill, A Maffioletti, V García-Molinero, F Stutz… - Cell Reports, 2020 - cell.com
Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently,
the transcription of long noncoding RNAs often overlaps with coding gene promoters …
the transcription of long noncoding RNAs often overlaps with coding gene promoters …