Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

The clinical challenge posed by p53 abnormalities in hematological malignancies requires
therapeutic strategies other than standard genotoxic chemotherapies. ONC201 is a first-in …

Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%)
and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease …

Leukemia stem cells are known to exhibit multidrug resistance by expression of ATP-binding
cassette (ABC) transporters which constitute transmembrane proteins capable of exporting a …

The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …

Glioma is the most common type of primary brain tumors. After standard treatment regimen
(surgical section, radiotherapy and chemotherapy), the average survival time remains …

The development of multidrug resistance to cancer chemotherapy is a major obstacle to the
effective treatment of human malignancies. It has been established that membrane proteins …