Polymerization of ethylene oxide, propylene oxide, and other alkylene oxides: synthesis, novel polymer architectures, and bioconjugation

J Herzberger, K Niederer, H Pohlit, J Seiwert… - Chemical …, 2016 - ACS Publications
The review summarizes current trends and developments in the polymerization of alkylene
oxides in the last two decades since 1995, with a particular focus on the most important …

PEGylation, successful approach to drug delivery

FM Veronese, G Pasut - Drug discovery today, 2005 - Elsevier
PEGylation defines the modification of a protein, peptide or non-peptide molecule by the
linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non …

Peptide and protein PEGylation: a review of problems and solutions

FM Veronese - Biomaterials, 2001 - Elsevier
The paper discusses general problems in using PEG for conjugation to high or low
molecular weight molecules. Methods of binding PEG to different functional groups in …

Polymer–drug conjugation, recent achievements and general strategies

G Pasut, FM Veronese - Progress in polymer science, 2007 - Elsevier
The field of drug delivery is fast expanding and its potentials have already been proved by
the many products in the market. Among all approaches, polymer conjugation is a well …

Chemistry of polyethylene glycol conjugates with biologically active molecules

S Zalipsky - Advanced drug delivery reviews, 1995 - Elsevier
Polyethylene glycol (PEG) is widely used as a covalent modifier of biological
macromolecules and particulates as well as a carrier for low molecular weight drugs. In the …

Coupling chemical modification and immobilization to improve the catalytic performance of enzymes

RC Rodrigues, Á Berenguer‐Murcia… - Advanced Synthesis …, 2011 - Wiley Online Library
Chemical modification and immobilization of enzymes have been usually considered
unrelated tools to improve biocatalyst features. However, there are many examples where a …

Polypeptide–polymer bioconjugates

LA Canalle, DWPM Löwik, JCM van Hest - Chemical Society Reviews, 2010 - pubs.rsc.org
Creating bioconjugates by combining polymers with peptides and proteins is an emerging
multidisciplinary field of research that has enjoyed increased attention within the scientific …

A branched monomethoxypoly (ethylene glycol) for protein modification

C Monfardini, O Schiavon, P Caliceti… - Bioconjugate …, 1995 - ACS Publications
Procedures are described for linking monomethoxypoly (ethylene glycol)(mPEG) to both e
and a amino groups of lysine. The lysine carboxyl group can then be activated as a …

Introduction to chemistry and biological applications of poly (ethylene glycol)

S Zalipsky, JM Harris - 1997 - ACS Publications
The chemistry and biological applications of polyethylene glycol (or" PEG") have been the
subject of intense study both in academics and in industry. The current volume contains 28 …

Biomedical and biotechnological applications of PEG-and PM-modified proteins

Y Inada, M Furukawa, H Sasaki, Y Kodera… - Trends in …, 1995 - cell.com
Chemical modification of proteins and other bioactive molecules with polyethylene glycol
(PEG) or its derivatives (PM) can be used to tailor molecular properties to particular …