Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

Background: Glutathione is a ubiquitous thiol-containing tripeptide, which plays a central
role in cell biology. It is implicated in the cellular defence against xenobiotics and naturally …

During normal cellular activities, various processes inside of cells produce reactive oxygen
species (ROS). Some of the most common ROS are hydrogen peroxide (H2O2), superoxide …

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …

An increasing body of evidence from animal models, human specimens and cell lines points
to reactive oxygen species as likely involved in the pathways, which convey both …