Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Background Deregulated gene expression is a hallmark of cancer; however, most studies to
date have analyzed short-read RNA sequencing data with inherent limitations. Here, we …

As a co-transcriptional process, RNA processing, including alternative splicing and
alternative polyadenylation, is crucial for the generation of multiple mRNA isoforms. RNA …

Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the
National Human Genome Research Institute to sequence thousands of tumors representing …

DNA wraps around histone octamers to assemble nucleosomes, which pack into high-
ordered chromatin structure in the nucleus, and block access to the genetic material. The …

CRISPR‐dCas9 systems that are precisely activated by cell‐specific information facilitate the
development of smart sensors or therapeutic strategies. We report the development of an …

Sarcomas are heterogeneous bone and soft tissue cancers representing the second most
common tumor type in children and adolescents. Histology and genetic profiling discovered …

Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors
converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although …

Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …