[HTML][HTML] Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine

H Tan, T Yue, Z Chen, W Wu, S Xu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Cardiovascular and metabolic disease (CVMD) is becoming increasingly prevalent in
developed and developing countries with high morbidity and mortality. In recent years …

Nose-to-brain delivery of stem cells in stroke: the role of extracellular vesicles

CV Borlongan, JY Lee, F D'Egidio… - Stem Cells …, 2024 - academic.oup.com
Stem cell transplantation offers a promising therapy that can be administered days, weeks,
or months after a stroke. We recognize 2 major mitigating factors that remain unresolved in …

Toll‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage

J Peng, Y Xie, J Pang, Y Wu, J Zhou… - Journal of …, 2023 - Wiley Online Library
Neuroinflammation has been reported to be associated with white matter injury (WMI) after
subarachnoid hemorrhage (SAH). As the main resident immune cells of the brain, microglia …

Disruption of sonic hedgehog signaling accelerates age-related neurogenesis decline and abolishes stroke-induced neurogenesis and leads to increased anxiety …

J Wang, K Ware, A Bedolla, E Allgire… - Translational stroke …, 2022 - Springer
Sonic Hedgehog (SHH) signaling has a critical role in mediating developmental
neurogenesis and has been implicated in adult subventricular (SVZ) neurogenesis …

Potential cerebrovascular protective functions of lycium barbarum polysaccharide in alleviating hyperglycemia-aggravated cerebral ischemia/reperfusion injury in …

HF Jiang, YQ Guo, FU Rehman… - European Review for …, 2022 - search.ebscohost.com
OBJECTIVE: Lycium barbarum polysaccharide (LBP) is the efficient primary compound of
Lycium barbarum and has been shown to alleviate hyperglycemia-aggravated cerebral …

The SGLT2 inhibitor Empagliflozin promotes post-stroke functional recovery in diabetic mice

E Vercalsteren, D Karampatsi, C Buizza… - Cardiovascular …, 2024 - Springer
Abstract Type-2 diabetes (T2D) worsens stroke recovery, amplifying post-stroke disabilities.
Currently, there are no therapies targeting this important clinical problem. Sodium-glucose …

The pre-stroke induction and normalization of insulin resistance respectively worsens and improves functional recovery

E Vercalsteren, D Karampatsi, D Dekens… - International Journal of …, 2023 - mdpi.com
Type 2 diabetes (T2D) impairs post-stroke recovery, and the underlying mechanisms are
unknown. Insulin resistance (IR), a T2D hallmark that is also closely linked to aging, has …

A tale of two fronts: novel experimental strategies to improve stroke outcome in type 2 diabetes

D Karampatsi - 2024 - openarchive.ki.se
BackgroundType 2 Diabetes (T2D) constitutes a critical health issue worldwide, which is
associated with poor stroke outcome and lasting disability. However, the exact mechanisms …

ФАКТОРЫ РОСТА ФИБРОБЛАСТОВ И ИХ ВЛИЯНИЕ НА КОГНИТИВНЫЕ ФУНКЦИИ И ТЕЧЕНИЕ ДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ ЦЕНТРАЛЬНОЙ …

ЕС ГУСЕВА, СО ДАВЫДОВ, НИ ЧАЛИСОВА - 2022 - elibrary.ru
Цель обзора. Изучение характеристик факторов роста фибробластов (FGFs), таких,
как фактор FGFd у человека, включающий 22 структурно связанных между собой …

Fibroblast growth factors and their effect on cognitive functions and the course of central nervous system degenerative diseases

BI Kuznik, ES Guseva, SO Davidov… - Molekulyarnaya …, 2022 - rjsvd.com
Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man
factor FGFd, including 22 structurally connected polypeptides, is necessary for the …