Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …

Basic applications of the information entropy concept to chemical objects are reviewed.
These applications deal with quantifying chemical and electronic structures of molecules …

Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …

The search for alien life is hard because we do not know what signatures are unique to life.
We show why complex molecules found in high abundance are universal biosignatures and …

Several definitions of molecular complexity exist to facilitate prioritization of lead
compounds, to identify diversity-inducing and complexifying reactions, and to guide …

Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel
arrangements not accessible by current biosynthesis pathways. As such they can be …

Small-molecule chemical probes or tools have become progressively more important in
recent years as valuable reagents to investigate fundamental biological mechanisms and …

Enantioselective construction of molecules bearing multiple stereogenic elements is
increasingly related to the synthesis of enantiopure natural products, pharmaceuticals, and …

Comparative life-cycle assessment (LCA) of pharmaceutical drugs would enable clinicians
to choose alternatives with lower environmental impact from options offering equivalent …