Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

Convergent evolution of defensin sequence, structure and function

TMA Shafee, FT Lay, TK Phan, MA Anderson… - Cellular and Molecular …, 2017 - Springer
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …

The defensins consist of two independent, convergent protein superfamilies

TMA Shafee, FT Lay, MD Hulett… - Molecular biology and …, 2016 - academic.oup.com
The defensin and defensin-like proteins are an extensive group of small, cationic, disulfide-
rich proteins found in animals, plants, and fungi and mostly perform roles in host defense …

Antifungal peptides and proteins to control toxigenic fungi and mycotoxin biosynthesis

PV Martínez-Culebras, M Gandía, S Garrigues… - International Journal of …, 2021 - mdpi.com
The global challenge to prevent fungal spoilage and mycotoxin contamination on food and
feed requires the development of new antifungal strategies. Antimicrobial peptides and …

Natural antimicrobial peptides as inspiration for design of a new generation antifungal compounds

M Bondaryk, M Staniszewska, P Zielińska… - Journal of fungi, 2017 - mdpi.com
Invasive fungal infections are associated with high mortality rates, despite appropriate
antifungal therapy. Limited therapeutic options, resistance development and the high …

Novel formulations for antimicrobial peptides

AM Carmona-Ribeiro, LDM Carrasco - International journal of molecular …, 2014 - mdpi.com
Peptides in general hold much promise as a major ingredient in novel supramolecular
assemblies. They may become essential in vaccine design, antimicrobial chemotherapy …

[HTML][HTML] Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction

K Sakamoto, SP Jin, S Goel, JH Jo, B Voisin, D Kim… - Immunity, 2021 - cell.com
Hair follicles (HFs) function as hubs for stem cells, immune cells, and commensal microbes,
which must be tightly regulated during homeostasis and transient inflammation. Here we …

Natural peptides inducing cancer cell death: Mechanisms and properties of specific candidates for cancer therapeutics

PA Trinidad-Calderón, CD Varela-Chinchilla… - Molecules, 2021 - mdpi.com
Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …

Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris

M Billamboz, Z Fatima, S Hameed, S Jawhara - Microorganisms, 2021 - mdpi.com
Invasive fungal infections represent an expanding threat to public health. During the past
decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida …