In the past decade, advances in the use of monoclonal antibodies (mAbs) and adoptive
cellular therapy to treat cancer by modulating the immune response have led to …

Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is highly promising but requires
robust T-cell expansion and engraftment. A T-cell defect in chronic lymphocytic leukemia …

Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population that
shares certain characteristics including an aberrant myeloid phenotype and the ability to …

Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to
profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or …

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, which is associated with
profound alterations and defects in the immune system and a prevalent dependency on the …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis …

Purpose: Patients with chronic lymphocytic leukemia (CLL) display immune deficiency that is
most obvious in advanced stage disease. Here we investigated whether this immune …

Chronic myeloid leukemia (CML) is a hematological cancer, characterized by a reciprocal
chromosomal translocation between chromosomes 9 and 22 [t (9; 22)], producing the Bcr …