WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Insulin-like growth factor-binding proteins (IGFBPs) 1–6 bind IGFs but not insulin with high
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …

Single-cell omics technologies enable molecular characterization of diverse cell types and
states, but how the resulting transcriptional and epigenetic profiles depend on the cell's …

Abstract The Wnt‐Frizzled (Fzd) G‐protein‐coupled receptor system, involving 19 distinct
Wnt ligands and 10 Fzd receptors, plays key roles in the development and functioning of …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

The IGF-binding protein family contains six members that share significant structural
homology. Their principal function is to regulate the actions of IGF1 and IGF2. These …

Regenerative medicine is a translational field which combines tissue engineering and
molecular biology to construct spare organs or help injured or defective tissues to …

The ability to repair damaged or lost tissues varies significantly among vertebrates. The
regenerative ability of the heart is clinically very relevant, because adult teleost fish and …

The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in
embryonic and neonatal development across species. In mammals the pathway is quiescent …

This article discusses current understanding of myocardial biology, emphasizing the
regeneration potential of the adult human heart and the mechanisms involved. In the last …