The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a
variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

Identifying the mechanism of action for antibacterial compounds is essential for
understanding how bacteria interact with one another and with other cell types and for …

Antibiotic resistance continues to hamper antimicrobial chemotherapy of infectious disease,
and while biocide resistance outside of the laboratory is as yet unrealized, in vitro and in …

Antibiotic resistance of bacterial pathogens is a fast emerging global crisis and an
understanding of the underlying resistance mechanisms is paramount for design and …

Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …

Recognition of some of the limitations of target-based drug discovery has recently led to the
renaissance of a more holistic approach in which complex biological systems are …

Microbial natural products are the origin of most of the antibiotics on the market today.
However, research in antibiotics and natural products has declined significantly during the …

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