Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …
programs that necessitate intricate synergic interactions between transcription factors and …
Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms
The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates
gene expression through its histone acetyltransferase and deubiquitylase activities …
gene expression through its histone acetyltransferase and deubiquitylase activities …
Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development
The Spt–Ada–Gcn5–acetyltransferase (SAGA) chromatin-modifying complex is a
transcriptional coactivator that contains four different modules of subunits. The intact SAGA …
transcriptional coactivator that contains four different modules of subunits. The intact SAGA …
Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders
Background Since RNA expression differences have been reported in autism spectrum
disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been …
disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been …
Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its
expression is reduced or lost in several cancers, including breast cancer. Using an …
expression is reduced or lost in several cancers, including breast cancer. Using an …
The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms
V Fischer, D Plassard, T Ye, B Reina-San-Martin… - Cell reports, 2021 - cell.com
Summary SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada-two-A-containing) are
two related coactivator complexes, sharing the same histone acetyltransferase (HAT) …
two related coactivator complexes, sharing the same histone acetyltransferase (HAT) …
A novel interaction of ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression
Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is
embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by …
embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by …
High-risk HPV16E6 stimulates hADA3 degradation by enhancing its SUMOylation
Despite significant research, our understanding of the molecular mechanisms of Human
Papilloma Virus (HPV) induced cancers remains incomplete. Majority of invasive cervical …
Papilloma Virus (HPV) induced cancers remains incomplete. Majority of invasive cervical …
Epidermal growth factor receptor activation promotes ADA3 acetylation through the AKT-p300 pathway
ABSTRACT The ADA3 (Alteration/Deficiency in Activation 3) protein is an essential adaptor
component of several L ysine A cetyl t ransferase (KAT) complexes involved in chromatin …
component of several L ysine A cetyl t ransferase (KAT) complexes involved in chromatin …
Cell cycle roles for GCN5 revealed through genetic suppression
EL Petty, L Pillus - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2021 - Elsevier
The conserved acetyltransferase Gcn5 is a member of several complexes in eukaryotic cells,
playing roles in regulating chromatin organization, gene expression, metabolism, and cell …
playing roles in regulating chromatin organization, gene expression, metabolism, and cell …