Biology of the TAM receptors
G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …
kinases, in that as a group they play no essential role in embryonic development. Instead …
TAM receptor signaling in immune homeostasis
CV Rothlin, EA Carrera-Silva, L Bosurgi… - Annual review of …, 2015 - annualreviews.org
The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons.
They degenerate in multiple neurological disorders. However, their role in the pathogenesis …
They degenerate in multiple neurological disorders. However, their role in the pathogenesis …
[HTML][HTML] Blood-brain barrier breakdown in the aging human hippocampus
The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells
into the brain that is essential for normal neuronal functioning and information processing …
into the brain that is essential for normal neuronal functioning and information processing …
Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke
R Wang, Y Zhu, Z Liu, L Chang, X Bai… - Blood, The Journal …, 2021 - ashpublications.org
Intracerebral hemorrhage associated with thrombolytic therapy with tissue plasminogen
activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here …
activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here …
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Z Zhao, AP Sagare, Q Ma, MR Halliday, P Kong… - Nature …, 2015 - nature.com
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …
[HTML][HTML] Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
RD Bell, EA Winkler, AP Sagare, I Singh, B LaRue… - Neuron, 2010 - cell.com
Pericytes play a key role in the development of cerebral microcirculation. The exact role of
pericytes in the neurovascular unit in the adult brain and during brain aging remains …
pericytes in the neurovascular unit in the adult brain and during brain aging remains …
The hemostatic system as a modulator of atherosclerosis
JI Borissoff, HMH Spronk… - New England Journal of …, 2011 - Mass Medical Soc
The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …
Skip to main content The New England Journal of Medicine homepage Advanced Search …
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
JHM van der Meer, T van der Poll… - Blood, The Journal of …, 2014 - ashpublications.org
Abstract TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases
that have important effects on hemostasis and inflammation. Also, they affect cell …
that have important effects on hemostasis and inflammation. Also, they affect cell …