Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms
J Korbecki, D Simińska… - International journal of …, 2021 - mdpi.com
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
The effect of hypoxia on the expression of CXC chemokines and CXC chemokine receptors—a review of literature
J Korbecki, K Kojder, P Kapczuk, P Kupnicka… - International journal of …, 2021 - mdpi.com
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …
Redox control of inflammation in macrophages
B Brüne, N Dehne, N Grossmann, M Jung… - Antioxidants & redox …, 2013 - liebertpub.com
Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …
cells, and have variable roles in a great number of pathological, but also physiological …
Role of hypoxia inducible factor-1 in cancer stem cells
Q Zhang, Z Han, Y Zhu, J Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function
SL Yang, C Wu, ZF Xiong… - Molecular medicine …, 2015 - spandidos-publications.com
Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …
Modeling the regulation of p53 activation by HIF‐1 upon hypoxia
As a famous tumor suppressor, p53 is also activated under hypoxic conditions. Hypoxia‐
inducuble factor 1, HIF‐1, is involved in the activation of p53 upon hypoxia. However, how …
inducuble factor 1, HIF‐1, is involved in the activation of p53 upon hypoxia. However, how …
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
K Dendoncker, S Timmermans… - Proceedings of the …, 2019 - National Acad Sciences
Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic
effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the …
effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the …
Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity
The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a
transcriptional program in response to reduced O 2 availability in metazoans. It contributes …
transcriptional program in response to reduced O 2 availability in metazoans. It contributes …
[HTML][HTML] Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate
NC Hait, A Maiti, P Xu, Q Qi, T Kawaguchi… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Abstract Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid
metabolite to generate sphingosine-1-phosphate (S1P). Nuclear S1P is involved in …
metabolite to generate sphingosine-1-phosphate (S1P). Nuclear S1P is involved in …