The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

In patients with uncomplicated essential hypertension, cardiac output remains within normal
ranges and intravascular volume is normal or low, assuming the presence of a sufficient …

Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

The steroid hormone aldosterone regulates sodium and potassium homeostasis.
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …

involves 2 different mechanisms. 1 The first is related to the development of a high-pressure
wave by the left ventricle that ejects into the proximal aorta (proximal compartment). The …

Objective—Aldosterone (Aldo) is involved in arterial stiffness and heart failure, but the
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …

The discovery of steroid hormone receptors in brain regions that mediate every aspect of
brain function has broadened the definition of 'neuroendocrinology'to include the reciprocal …

Physical stiffening of the large arteries is the central paradigm of vascular aging. Indeed,
stiffening in the larger central arterial system, such as the aortic tree, significantly contributes …