Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Descriptions of insulitis in human islets throughout the natural history of type 1 diabetes are
limited. We determined insulitis frequency (the percent of islets displaying insulitis to total …

Methods Eleven people with type 2 diabetes (49.5±2.5 years, BMI 33.6±1.2 kg/m 2, nine
male and two female) were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 …

Exocrine pancreatic insufficiency (EPI) is a condition caused by reduced or inappropriate
secretion or activity of pancreatic juice and its digestive enzymes, pancreatic lipase in …

A growing body of evidence is pointing out the pathophysiological role of fat accumulation in
different organs. Ectopic fat depots within heart, liver, skeletal muscle, kidney, and pancreas …

We discuss how obesity may contribute to increasing acute pancreatitis incidence, the role
of lipolytic unsaturated fatty acid release in worsening acute pancreatitis, and potential …

Background The pancreas is small and irregular in shape in people with type 2 diabetes. If
these abnormalities are caused by the disease state itself rather than being a predisposing …

Obesity increases the risk of adverse outcomes during acute critical illnesses such as burns,
severe trauma, and acute pancreatitis. Although individuals with more body fat and higher …