Controversies in HIV-associated neurocognitive disorders

S Nightingale, A Winston, S Letendre… - The Lancet …, 2014 - thelancet.com
Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …

The challenge of viral reservoirs in HIV-1 infection

JN Blankson, D Persaud… - Annual review of …, 2002 - annualreviews.org
▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a
replication-competent form of the virus accumulates and persists with more stable kinetic …

Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients …

LA Cysique, P Maruff, BJ Brew - Journal of neurovirology, 2004 - Springer
The objective of this study was to assess the prevalence and pattern of neuropsychological
impairment in cohorts of human immunodeficiency virus (HIV)-infected individuals across …

Neuropsychological functioning and antiretroviral treatment in HIV/AIDS: a review

LA Cysique, BJ Brew - Neuropsychology review, 2009 - Springer
This article presents a review of studies that have investigated the neuropsychological
effects of antiretroviral treatment (ART) for HIV-1 infection. It provides a brief overview of the …

Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral …

S Spudich, M Gisslen, L Hagberg, E Lee… - Journal of Infectious …, 2011 - academic.oup.com
Background. Central nervous system (CNS) human immunodeficiency virus (HIV) infection
and immune activation lead to brain injury and neurological impairment. Although HIV …

Where does HIV live?

J Stebbing, B Gazzard, DC Douek - New England Journal of …, 2004 - Mass Medical Soc
This survey of the cellular and anatomical sites of infection by human immunodeficiency
virus (HIV) discusses the mechanisms of attachment of the virus to cells, the cellular …

HIV in body fluids during primary HIV infection: implications for pathogenesis, treatment and public health

CD Pilcher, DC Shugars, SA Fiscus, WC Miller… - Aids, 2001 - journals.lww.com
HIV in body fluids during primary HIV infection: implication... : AIDS HIV in body fluids during
primary HIV infection: implications for pathogenesis, treatment and public health : AIDS Log in or …

T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy

G Lustig, S Cele, F Karim, A Derache, A Ngoepe… - PLoS …, 2021 - journals.plos.org
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in
CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine …

Human immunodeficiency virus type 1 RNA Levels in different regions of human brain: quantification using real-time reverse transcriptase-polymerase chain reaction

AM Kumar, I Borodowsky, B Fernandez… - Journal of …, 2007 - Springer
Human immunodeficiency virus type 1 (HIV-1) enters the central nervous system shortly after
the infection and becomes localized in different regions of the brain, leading to various …

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

A Cusini, PL Vernazza, S Yerly… - JAIDS Journal of …, 2013 - journals.lww.com
Objectives: To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated
patients and to evaluate if combination antiretroviral treatments with higher central nervous …