Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

Breast cancer represents the most prevalent form of cancer and the leading cause of cancer-
related mortality among females worldwide. It has been reported that several risk factors …

The tumor microenvironment (TME) presents differential selective pressure (DSP) that favors
the growth of cancer cells, and monovalent therapy is often inadequate in reversing the …

The field of bacteria-based cancer therapy, which focuses on the key role played by the
prevalence of bacteria, specifically in tumors, in controlling potential targets for cancer …

Radiotherapy widely applied for local tumor therapy in clinic has been recently reinvigorated
by the discovery that radiotherapy could activate systematic antitumor immune response …

The condensed extracellular matrix (ECM) surrounding cancer cells results in the formation
of a biophysical barrier versus chemotherapeutic drug penetration into deeper regions of …

Certain bacteria demonstrate the ability to target and colonize the tumor microenvironment,
a characteristic that positions them as innovative carriers for delivering various therapeutic …

Tumor malignancy highly depends on the stiffness of tumor matrix, which mainly consists of
collagen. Despite the destruction of tumor matrix is conducive to tumor therapy, it causes the …

Cancer remains the leading cause of human death worldwide. Compared to traditional
therapies, tumor immunotherapy has received a lot of attention and research focus due to its …

Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal cancers in the world and its 5-
year survival rate is< 10%. Due to the unique TME and dense tissue structure, its curative …