Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the
treatment of a variety of human diseases. Recent advances in developing clinically …

The unique life cycle of adeno-associated virus (AAV) and its ability to infect both
nondividing and dividing cells with persistent expression have made it an attractive vector …

This study examines transgene expression and biodistribution of adeno-associated virus
(AAV) pseudotyped 1–9 after tail vein (TV) injection in male mice. Using a cytomegalovirus …

Recombinant adeno-associated viral (AAV) vectors have rapidly advanced to the forefront of
gene therapy in the past decade. The exponential progress of AAV-based vectors has been …

After over 20years from the first application of gene transfer in humans, gene therapy is now
a mature discipline, which has progressively overcome several of the hurdles that prevented …

Sequence analysis revealed phospholipase A 2 (PLA 2) motifs in capsid proteins of
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …

▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in
receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and …

Numerous virus families utilize endocytosis to infect host cells, mediating virus
internalization as well as trafficking to the site of replication. Recent research has …

In the last two decades, recombinant adeno-associated virus has emerged as the most
popular gene therapy vector. Recently AAV gene therapy has been approved by the FDA for …

Adeno-associated virus (AAV) based vectors have emerged as important tools for gene
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …