The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …

The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has
been established as a key player in the pathogenesis of migraine. In this study, we provide …

Our conceptual understanding of the molecular architecture of G-protein coupled receptors
(GPCRs) has transformed over the last decade. Once considered as largely independent …

Calcitonin gene-related peptides (α and β isoforms), better known as CGRPα and CGRPβ,
were isolated 20 years ago. In fact, these were the first peptides to be characterized using a …

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to
encompass novel protein interactions that underlie both cell-surface receptor expression …

Epicardial white adipose tissue (eWAT) is in close contact with coronary vessels and
therefore could alter coronary homeostasis. Adrenomedullin (AM) is a potent vasodilatator …

Clinical evidence indicates that female sex steroids may contribute to the high prevalence of
migraine in women, as well as changes in the frequency or severity of migraine attacks that …

The calcitonin peptides [calcitonin (CT), calcitonin gene-related peptide (CGRP), amylin]
share many biological actions, including activity on bone cells. In the present study, CT (10 …

Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the
vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of …