Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-
3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9 …

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …

Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation
in coincubated nuclei after it is activated by caspase-3. This protein, designated DNA …

Histone H2AX is a ubiquitous member of the H2A histone family that differs from the other
H2A histones by the presence of an evolutionarily conserved C-terminal motif …

Apoptosis or programmed cell death (PCD) is a genetically regulated, cellular suicide
mechanism that plays a crucial role in development and in the defense of homeostasis …