The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Dicarbonyl stress occurs when dicarbonyl metabolites (ie, methylglyoxal, glyoxal and 3-
deoxyglucosone) accumulate as a consequence of their increased production and/or …

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of
glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation …

Late vascular complications play a prominent role in the diabetes-induced increase in
morbidity and mortality. Diabetes mellitus is recognised as a risk factor driving …

Background Methylglyoxal (MGO) is the most potent precursor of advanced glycation end
products (AGEs). MGO and AGEs have been associated with diabetes, its complications …

Background Hyperglycemia and increased levels of methylglyoxal (MGO) can trigger the
development of vascular complications in diabetes. Resveratrol and quercetin are red wine …

Background The cardiovascular benefits of resveratrol (RSV) have been well established by
previous experimental and clinical studies. The aim of this study was to investigate the …

Background Increased levels of the sugar metabolite methylglyoxal (MG) in vivo were shown
to participate in the pathophysiology of vascular complications in diabetes. Alterations of …

BACKGROUND: Preeclampsia is a multifaceted syndrome that includes maternal vascular
dysfunction. We hypothesize that increased placental glycolysis and hypoxia in …

Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) are major cell types that
control vascular function, and hence dysfunction of these cells plays a key role in the …