Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
[HTML][HTML] Synapse pathology in Alzheimer's disease
J Griffiths, SGN Grant - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to
the onset and progression of its behavioural and physiological features. Here we review the …
the onset and progression of its behavioural and physiological features. Here we review the …
Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
JS Bhatti, S Kaur, J Mishra, H Dibbanti, A Singh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology
through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal …
through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal …
Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model
W Chen, Q Huang, EK Lazdon… - Proceedings of the …, 2023 - National Acad Sciences
Brain insulin signaling controls peripheral energy metabolism and plays a key role in the
regulation of mood and cognition. Epidemiological studies have indicated a strong …
regulation of mood and cognition. Epidemiological studies have indicated a strong …
A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: statistical approach vs machine learning approach
Alzheimer's Disease (AD) is a neurodegenerative disease that affects cognition and is the
most common cause of dementia in the elderly. As the number of elderly individuals …
most common cause of dementia in the elderly. As the number of elderly individuals …
Neurobiological highlights of cognitive impairment in psychiatric disorders
This review is focused on several psychiatric disorders in which cognitive impairment is a
major component of the disease, influencing life quality. There are plenty of data proving that …
major component of the disease, influencing life quality. There are plenty of data proving that …
[HTML][HTML] Mitochondrial dysfunction in Alzheimer's disease: opportunities for drug development
Alzheimer's disease (AD) is one of the major reasons for 60-80% cases of senile dementia
occurring as a result of the accumulation of plaques and tangles in the hippocampal and …
occurring as a result of the accumulation of plaques and tangles in the hippocampal and …
Dysfunction of mitochondria in Alzheimer's disease: ANT and VDAC interact with toxic proteins and aid to determine the fate of brain cells
Alzheimer's disease (AD), certainly the most widespread proteinopathy, has as classical
neuropathological hallmarks, two groups of protein aggregates: senile plaques and …
neuropathological hallmarks, two groups of protein aggregates: senile plaques and …