[HTML][HTML] Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory disease. The disease has a
multifactorial aetiology, involving genetic, microbial as well as environmental factors. The …
multifactorial aetiology, involving genetic, microbial as well as environmental factors. The …
Fat-soluble vitamins and the current global pandemic of COVID-19: evidence-based efficacy from literature review
N Samad, S Dutta, TE Sodunke, A Fairuz… - Journal of …, 2021 - Taylor & Francis
The outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2), later named COVID-19 by the World Health Organization (WHO), was …
(SARS-CoV-2), later named COVID-19 by the World Health Organization (WHO), was …
[HTML][HTML] Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection
Interactions between the microbiota and mammalian host are essential for defense against
infection, but the microbial-derived cues that mediate this relationship remain unclear. Here …
infection, but the microbial-derived cues that mediate this relationship remain unclear. Here …
[HTML][HTML] Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …
[HTML][HTML] Gut commensals expand vitamin A metabolic capacity of the mammalian host
Conversion of dietary vitamin A (VA) into retinoic acid (RA) is essential for many biological
processes and thus far studied largely in mammalian cells. Using targeted metabolomics …
processes and thus far studied largely in mammalian cells. Using targeted metabolomics …
[HTML][HTML] Nuclear receptors as multiple regulators of NLRP3 inflammasome function
A Alatshan, S Benkő - Frontiers in Immunology, 2021 - frontiersin.org
Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …
responses. Beside their role in several developmental and physiological processes, many of …
Innate immune sensing by epithelial barriers
Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting,
and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern …
and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern …
[HTML][HTML] Epithelial inflammasomes in the defense against Salmonella gut infection
Highlights•NAIP/NLRC4 and Caspase-4/11 inflammasomes restrict S. Tm infection of gut
epithelium.•Importance of NAIP/NLRC4 versus Caspase-4/11 may shift between early and …
epithelium.•Importance of NAIP/NLRC4 versus Caspase-4/11 may shift between early and …
[HTML][HTML] Vitamin A: A key coordinator of host-microbe interactions in the intestine
YJ Bang - BMB reports, 2023 - ncbi.nlm.nih.gov
The human intestine is home to a dense community of microbiota that plays a key role in
human health and disease. Nutrients are essential regulators of both host and microbial …
human health and disease. Nutrients are essential regulators of both host and microbial …
[HTML][HTML] Early nutrition and risk of type 1 diabetes: the role of gut microbiota
E Verduci, C Mameli, M Amatruda, A Petitti… - Frontiers in …, 2020 - frontiersin.org
Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing
incidence in the last decades. Although the genetic predisposition is a major risk factor, it …
incidence in the last decades. Although the genetic predisposition is a major risk factor, it …