Recent progress on gene-deleted live-attenuated African swine fever virus vaccines

HLX Vu, DS McVey - npj Vaccines, 2024 - nature.com
Abstract African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality
rates approaching 100%. The disease has spread to many swine-producing countries …

Modulation of host antiviral innate immunity by African swine fever virus: a review

WR He, J Yuan, YH Ma, CY Zhao, ZY Yang, Y Zhang… - Animals, 2022 - mdpi.com
Simple Summary Immune evasion is a prerequisite for successful viral infection, and viral
proteins involved in regulating host antiviral innate immunity have always been the …

Combinational deletions of MGF360-9L and MGF505-7R attenuated highly virulent African swine fever virus and conferred protection against homologous challenge

M Ding, W Dang, H Liu, F Xu, H Huang… - Journal of …, 2022 - Am Soc Microbiol
Multigene family (MGF) gene products are increasingly reported to be implicated in African
swine fever virus (ASFV) virulence and attenuation of host defenses, among which the …

Development and application of a colloidal-gold dual immunochromatography strip for detecting African swine fever virus antibodies

Y Wan, Z Shi, G Peng, L Wang, J Luo, Y Ru… - Applied Microbiology …, 2022 - Springer
African swine fever (ASF) is an acute and highly contagious infectious disease caused by
the African swine fever virus (ASFV). Currently, there is no vaccine against ASF worldwide …

African swine fever virus MGF505-7R interacts with interferon regulatory factor 9 to evade the type I interferon signaling pathway and promote viral replication

Z Huang, H Cao, F Zeng, S Lin, J Chen, Y Luo… - Journal of …, 2023 - Am Soc Microbiol
African swine fever (ASF) is an acute and severe infectious disease caused by the ASF virus
(ASFV). The mortality rate of ASF in pigs can reach 100%, causing huge economic losses to …

African swine fever virus MGF110-7L induces host cell translation suppression and stress granule formation by activating the PERK/PKR-eIF2α pathway

H Zhong, S Fan, Y Du, Y Zhang, A Zhang… - Microbiology …, 2022 - Am Soc Microbiol
African swine fever (ASF) is a highly contagious and often lethal disease of pigs caused by
ASF virus (ASFV) and recognized as the biggest killer in global swine industry. Despite …

Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B …

G Zhu, J Ren, D Li, Y Ru, X Qin, T Feng, H Tian… - Journal of …, 2023 - Am Soc Microbiol
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a
transboundary infectious disease of domestic pigs and wild boars, resulting in significant …

Identification of two Linear epitopes on MGF_110-13L protein of African swine fever virus with monoclonal antibodies

SJ Zhang, B Niu, SM Liu, YM Zhu, DM Zhao, ZG Bu… - Animals, 2024 - mdpi.com
Simple Summary Due to the complexity of the structure of African swine fever virus (ASFV),
the structure and function of most viral encoded proteins are uncharacterized. A full …

Antagonisms of ASFV towards host defense mechanisms: knowledge gaps in viral immune evasion and pathogenesis

L Yu, Z Zhu, J Deng, K Tian, X Li - Viruses, 2023 - mdpi.com
African swine fever (ASF) causes high morbidity and mortality of both domestic pigs and wild
boars and severely impacts the swine industry worldwide. ASF virus (ASFV), the etiologic …

Involvement of the MGF 110-11L Gene in the African Swine Fever Replication and Virulence

V Tamás, C Righi, I Mészáros, F D'Errico, F Olasz… - Vaccines, 2023 - mdpi.com
African swine fever (ASF) is a highly lethal hemorrhagic viral disease that causes extensive
economic and animal welfare losses in the Eurasian pig (Sus scrofa) population. To date, no …